Examining the effects of caffeine and saccharin on acute ethanol intake in male C57BL/6J mice.

Caffeine is the most consumed psychoactive drug in the world yet animal research has been unable to establish caffeine as a reinforcer. However, caffeine functions as a reinforcement enhancer, potentiating motivation to obtain reinforcers. The combination of alcohol with caffeine…

Saccharin Potentiates Oral Ethanol Self-Administration in Male C57BL/6J Mice.

Alcohol is one of the most consumed substances by humans and is typically consumed with appetitive stimuli (juice, soft drinks, etc.) that may potentiate consumption. Remarkably, preclinical alcohol self-administration research is often difficult to establish. Researchers rely on alcohol-preferring strains…