{"id":324,"date":"2021-04-06T15:47:18","date_gmt":"2021-04-06T15:47:18","guid":{"rendered":"https:\/\/wp.bridgewater.edu\/?p=324"},"modified":"2021-04-09T17:07:04","modified_gmt":"2021-04-09T17:07:04","slug":"saccharin-potentiates-oral-ethanol-self-administration-in-male-c57bl-6j-mice","status":"publish","type":"post","link":"https:\/\/wp.bridgewater.edu\/aspire\/2021\/04\/06\/saccharin-potentiates-oral-ethanol-self-administration-in-male-c57bl-6j-mice\/","title":{"rendered":"Saccharin Potentiates Oral Ethanol Self-Administration in Male C57BL\/6J Mice."},"content":{"rendered":"\n<p>Alcohol is one of the most consumed substances by humans and is typically consumed with appetitive stimuli (juice, soft drinks, etc.) that may potentiate consumption. Remarkably, preclinical alcohol self-administration research is often difficult to establish. Researchers rely on alcohol-preferring strains of animals or fading alcohol in slowly to a sucrose solution for self-administration. The current study investigated the relationship between alcohol self-administration and co-presentations of saccharin. We hypothesized that saccharin would increase alcohol self-administration compared to alcohol alone. Eighteen mice were separated into two reinforcer groups: ethanol and ethanol+saccharin. During 1-hr sessions, mice could lever press on a Progressive Ratio schedule of reinforcement for access to a designated reinforcer. Sessions continued for five days at each ethanol concentration (0%, 5%, 10%, 15%, 20%, and 25%). Active lever presses, inactive lever presses, reinforcers earned, and dose were recorded and analyzed for group differences.<\/p>\n\n\n<div class=\"ead-preview\"><div class=\"ead-document\" style=\"position:relative;\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fwp.bridgewater.edu%2Fwp-content%2Fuploads%2Fsites%2F2424%2F2021%2F04%2FSAC1-Pilot-Poster-ASPIRE-2021.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" style=\"width:100%; height:500px; border: none;\"><\/iframe><\/div><p class=\"embed_download\"><a href=\"https:\/\/wp.bridgewater.edu\/wp-content\/uploads\/sites\/2424\/2021\/04\/SAC1-Pilot-Poster-ASPIRE-2021.pdf\" download>Download<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"<div class=\"entry-summary\">\nAlcohol is one of the most consumed substances by humans and is typically consumed with appetitive stimuli (juice, soft drinks, etc.) that may potentiate consumption. Remarkably, preclinical alcohol self-administration research is often difficult to establish. Researchers rely on alcohol-preferring strains&hellip;\n<\/div>\n<div class=\"link-more\"><a href=\"https:\/\/wp.bridgewater.edu\/aspire\/2021\/04\/06\/saccharin-potentiates-oral-ethanol-self-administration-in-male-c57bl-6j-mice\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &ldquo;Saccharin Potentiates Oral Ethanol Self-Administration in Male C57BL\/6J Mice.&rdquo;<\/span>&hellip;<\/a><\/div>\n","protected":false},"author":210,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-324","post","type-post","status-publish","format-standard","hentry","category-uncategorized","entry"],"_links":{"self":[{"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/posts\/324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/users\/210"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/comments?post=324"}],"version-history":[{"count":6,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/posts\/324\/revisions"}],"predecessor-version":[{"id":430,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/posts\/324\/revisions\/430"}],"wp:attachment":[{"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/media?parent=324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/categories?post=324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.bridgewater.edu\/aspire\/wp-json\/wp\/v2\/tags?post=324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}